An internet parody of The Simpsons - called The OJ Simpsons - has come under fire from 20th Century Fox.
The OJ Simpsons feature Simpson as the Homer character
The studio has asked online video site Broadcaster.com to take down three animated clips that re-imagine the series with the ex-American footballer.
Broadcaster said it was reviewing the demand, but added that parodies are protected by fair-use doctrine.
The three OJ Simpsons clips are titled Black and White Christmas, Warzone and If I Did It.
If I Did It refers to Fox and its decision to withdraw publication of Simpson's proposed book about the murder of his ex-wife, Nicole Brown Simpson, and her friend Ronald Goldman.
The Simpsons is a massive global TV hit
The clips also parody the opening scene of The Simpsons, with Simpson being chased by several police cars.
He was famously chased on live TV in the US, after the pair were found dead in Los Angeles in June 1994.
Simpson was later found not guilty of the murders.
Broadcaster.com chief-executive Martin Wade said: "We respect the rights of content owners."
"We are examining all the issues raised by the Fox request.
"Our goal is to be a respecter of content rights and at the same time find legal ways to bring our community members the content they enjoy."
Fox, which declined comment, has been aggressive about protecting perceived copyright infringements.
In January, the studio forced Google to remove uploaded episodes of 24 and The Simpsons.