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Last Updated: Thursday, 24 May 2007, 11:58 GMT 12:58 UK
Transplant boy preparing for op
The Hartley boys
Luke Hartley (front, right) will finally have his life-saving operation
The last of four brothers diagnosed with a rare fatal illness will go into hospital for life-saving treatment.

Luke Hartley and his brothers Daniel, Nathan and Joshua , from Romsey, Hants, suffer from the genetic disorder XLP.

Joshua, 15, Daniel, 11, and Nathan, 13, have all had bone marrow transplants, only Luke, seven, has not.

He will undergo 10 days of chemotherapy to destroy his bone marrow to make room for a new marrow transplant in June at London's Great Ormond Street Hospital.

Nathan will donate his bone marrow, which will be extracted through a needle injected in his thigh while he is unconscious by doctors at the hospital.

We have to cross this last hurdle, when Luke goes back to school that day will be amazing
The brothers' father, David Hartley

He will stay in overnight and will feel sore for a few days.

The brothers' father, David Hartley, 44, said: "Nathan realises he is doing a huge thing for his brother so it's a relatively small sacrifice."

The siblings were diagnosed with XLP (X-Linked Lymphoproliferative Syndrome), or Duncan's Syndrome, which attacks the immune system, in November 2003.

Their parents, David and his wife Allison, 40, were told their sons were unlikely to reach their teenage years without a bone marrow transplant.

Joshua had his operation in 2004 after his mother was found to be a match.

Nathan and Daniel found donors after thousands responded to a massive campaign by the Anthony Nolan Trust.

'Absolutely devastating'

XLP is one of the world's rarest fatal disorders affecting about 100 families world-wide.

Mr Hartley added: "XLP is a time bomb and it can go off very quickly and the results can be absolutely devastating.

"Whilst Luke is incredibly well at the moment we know if he doesn't go through this process at some point in the not too distant future we would face a major problem.

"We have to cross this last hurdle. When Luke goes back to school, probably in October or November, that day will be amazing.

"We know we still have a long march along this path but at least we can see the end now."




SEE ALSO
Transplant brother's charity walk
22 May 05 |  Hampshire
Transplant brother marks birthday
22 Jan 05 |  Hampshire
Transplant brother back to school
19 Jan 05 |  Hampshire
Transplant brother returns home
17 Jan 05 |  Hampshire
Donor success for second brother
30 Nov 04 |  Hampshire
Family renews appeal for donors
22 Nov 04 |  Health
Second brother set for transplant
22 Sep 04 |  Hampshire
Bone marrow boy back with family
23 Aug 04 |  Hampshire
Brothers find life-saving donors
12 Jul 04 |  Hampshire/Dorset
Mother donates bone marrow to son
09 Jun 04 |  Hampshire/Dorset

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