Fears have been raised for the safety of a Bafta-nominated make-up artist who has gone missing.
Diane Chenery-Wickens failed to turn up at a hair salon
Diane Chenery-Wickens, 48, travelled from East Grinstead to London by train with her husband David last Thursday.
She had a meeting at the BBC in London, and was due to meet her husband at a hair salon later, but did not arrive.
Impressionist Jon Culshaw said he was hoping for a "sensible explanation". Detectives have appealed to the public for information.
Mrs Chenery-Wickens, from Duddleswell, East Sussex, has worked for more than 20 years on hair and make-up design on some of television's best-known shows, including the League of Gentleman, Casualty, Pride and Prejudice and Dead Ringers.
Culshaw, who starred in the comedy show Dead Ringers, told BBC South East: "We know her really, really well. She has been our make-up artist on our show for about five years.
Impressionist Jon Culshaw is concerned at the disappearance
"We spend a lot of time together and she is a really, really lovely woman, very organised. It's just really out of character which makes it all the more concerning and bewildering.
"You just hope that somewhere there is one of those sensible explanations to this."
Her brother, Russell Wickens, added their parents were "frantic" with worry and he urged her to make contact, saying: "We can solve anything."
In a statement, he said: "Diane's husband, her family and friends are all extremely worried.
"Her disappearance is uncharacteristic behaviour and causing us great concern. We urge her to get in touch just to let us know she is safe."
Det Insp Phil Mays, of Sussex Police, said Mrs Chenery-Wickens seemed to be a "well-organised", and "reliable" woman who did not let people down or break appointments, which had led to concern.
On the day she was last seen by her husband, she was wearing a brown suede jacket, brown calf-length boots, blue jeans and a black scarf.